In 2017, while he was still in college, Gooding found a manager and an agent and started booking roles.He booked his first major acting role in the HBO’s dramedy Ballers opposite Dwayne Johnson. In 2018, Gooding booked his first major film role in Booksmart directed by Olivia Wilde in her directorial debut. In 2019, Gooding was cast as Andrew in Love, Victor, the television spinoff of the 2018 film Love, Simon. Originally developed for Disney+, the series premiered on Hulu in 2020. While he played football in high school, Gooding had to learn how to play basketball for the role. Gooding also appeared in Netflix’s Christmas themed romantic comedy Let It Snow later that year. In 2020, he began appearing in Freeform’s sitcom, Everything’s Gonna Be Okay. In September 2020, Gooding was cast as Chad Meeks-Martin in the fifth Scream film, which was directed by Matt Bettinelli-Olpin and Tyler Gillett. The film was released on January 14, 2022.

In late August, Gooding co-starred alongside Kesha and Chloe Bailey in the scripted podcast, Electric Easy, a musical neo-noir science fiction show set in a futuristic Los Angeles in which humans struggle to co-exist with robots, known as “electrics”. The show was created by Vanya Asher and executively produced by Kesha. The podcast premiered on August 30, 2021. Gooding reprised his role of Chad Meeks-Martin in the film Scream VI, released on March 10, 2023.